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We briefly report on some particular aspects of new physics searches concerning, on the one side, the CKM paradigm and, on the other, the global fit to rare observables including lepton flavour universality ones. We put special emphasis on the state-of-the-art of hadronic uncertainties of observables and LFUV in SM and in presence of New Physics. Finally, we discuss the latest experimental and theoretical developments concerning long-distance charm contributions.

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