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The Holevo Cram'er Rao bound is a lower bound on the sum of the mean square error of estimates for parameters of a state. We provide a method for calculating the Holevo Cram'er-Rao bound for estimation of quadrature mean parameters of a Gaussian state by formulating the problem as a semidefinite program. In this case, the bound is tight; it is attained by purely Guassian measurements. We consider the example of a symmetric two-mode squeezed thermal state undergoing an unknown displacement on one mode. We calculate the Holevo Cram'er-Rao bound for joint estimation of the conjugate parameters for this displacement. The optimal measurement is different depending on whether the state is entangled or separable.

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