A possible dark matter (DM) explanation about the long-standing issue of the Galactic 511 keV line is explored in this paper. For DM cascade annihilations of concern, a DM pair annihilates into unstable , and decays into with new interactions suggested by the Be anomaly. Considering the constraints from the effective neutrino number and the 511 keV gamma-ray emission, a range of DM is obtained, $11.6 \lesssim m_{\pi_d^{\pm}} \lesssim 15\times$ cm s, which can give an explanation about the 511 keV line. The MeV scale DM may be searched by the DM-electron scattering, and the upper limit set by the CMB s-wave annihilation is derived in DM direct detections.

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