We present a nonperturbative Hamiltonian framework (NPHF) to address the general -body problem. This framework rigorously connects finite-volume spectra from lattice QCD to scattering observables from experiment. To demonstrate its applicability, we extract the resonance parameters of the meson by simultaneously analyzing the isoscalar and isovector systems. The Hamiltonian unifies single-particle , two-particle , and three-particle dynamics within a single unitary formalism. Using leading lattice QCD spectra from the Chinese Lattice QCD Collaboration at = 208 and 305 MeV, we perform a fit in the isovector and isoscalar channels, accurately describe the lattice spectra and obtain robust determinations of the and pole positions. This work establishes a foundational approach for extracting resonance dynamics from finite-volume spectra. Given the ubiquity of three-body dynamics in exotic hadrons, halo nuclei, and neutron star matter, this general formalism holds broad relevance across particle, nuclear, and astrophysical physics.

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