C*-Algebraic Higher Signatures and an Invariance Theorem in Codimension Two

We revisit the construction of signature classes in C*-algebra K-theory, and develop a variation that allows us to prove equality of signature classes in some situations involving homotopy equivalences of noncompact manifolds that are only defined outside of a compact set. As an application, we prove a counterpart for signature classes of a codimension two vanishing theorem for the index of the Dirac operator on spin manifolds (the latter is due to Hanke, Pape and Schick, and is a development of well-known work of Gromov and Lawson).