The determination of transverse single-spin asymmetries in experiments involving polarized targets and/or beams may encounter challenges when (1) the magnitude of the polarization varies greatly with time, (2) the polarization magnitude is not the same for each spin state, (3) different integrated luminosities occur for different spin states or different target materials, and/or (4) some kinematic variables require unfolding; these are just a few examples. We present general methods of determining the asymmetry based on both binned analysis and unbinned maximum likelihood optimization, incorporating the unfolding of kinematic variables that are smeared by detector effects, and also including the possibility of background subtraction.

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