We use 413 weeks of publicly-available Pass 8 gamma-ray data, combined with recently-developed galaxy group catalogs, to search for evidence of dark matter annihilation in extragalactic halos. In our study, we use luminosity-based mass estimates and mass-to-concentration relations to infer the -factors and associated uncertainties for hundreds of galaxy groups within a redshift range . We employ a conservative substructure boost-factor model, which only enhances the sensitivity by an factor. No significant evidence for dark matter annihilation is found and we exclude thermal relic cross sections for dark matter masses below 30 GeV to 95% confidence in the annihilation channel. These bounds are comparable to those from Milky Way dwarf spheroidal satellite galaxies. The results of our analysis increase the tension, but do not rule out, the dark matter interpretation of the Galactic Center excess. We provide a catalog of the galaxy groups used in this study and their inferred properties, which can be broadly applied to searches for extragalactic dark matter.

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