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The -polynomial was introduced by Deutsch and Klav\v{z}ar in 2015 as a graph polynomial to provide an easy way to find closed formulas of degree-based topological indices, which are used to predict physical, chemical, and pharmacological properties of organic molecules. In this paper we give general closed forms of the -polynomial of the generalized M"obius ladder and its line graph. We also compute Zagreb Indices, generalized Randi'c indices, and symmetric division index of these graphs via the -polynomial.

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