By Descartes’ rule of signs, a real degree polynomial with all nonvanishing coefficients, with sign changes and sign preservations in the sequence of its coefficients () has positive and negative roots, where , mod and $neg\equiv p(2)1\leq d\leq 3$, for every possible choice of the sequence of signs of coefficients of (called sign pattern) and for every pair $(pos, neg)Pposnegd\geq 44\leq d\leq 10$, in all nonrealizable cases either or . It was conjectured that this is the case for any . We show a counterexample to this conjecture for . Namely, we prove that for the sign pattern and the pair there exists no polynomial with positive, negative simple roots and a complex conjugate pair.

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