In this paper, we study linear transformations of the form where is an orthogonal polynomial system. Of particular interest is understanding when these operators preserve real-rootedness in polynomials. It is known that when the are the Hermite polynomials or standard Laguerre polynomials, the transformation has this property. It is also known that the transformation , where is the th generalized Hermite Polynomial with real parameter , has the differential operator representation . The main result of this paper is to prove that a differential operator of the form induces a system of monic orthogonal polynomials if and only if $\sum_{k=0}^\infty \frac{\gamma_k}{k!} D^k=\gamma_0e^{-\frac{ \alpha}{2}D^2-\beta D}\gamma_0,\alpha,\beta \in \alpha,\gamma_0 \neq 0$. This operator will produce a shifted set of generalized Hermite polynomials when . We also express the transformation from the standard basis to the standard Laguerre basis, as a differential operator of the form where the are polynomials, an identity that has not previously been shown.

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