To improve our understanding of high-z galaxies we study the impact of H chemistry on their evolution, morphology and observed properties. We compare two zoom-in high-resolution (30 pc) simulations of prototypical galaxies at . The first, “Dahlia”, adopts an equilibrium model for H formation, while the second, “Alth{\ae}a”, features an improved non-equilibrium chemistry network. The star formation rate (SFR) of the two galaxies is similar (within 50%), and increases with time reaching values close to 100 at . They both have SFR-stellar mass relation consistent with observations, and a specific SFR of . The main differences arise in the gas properties. The non-equilibrium chemistry determines the H H~transition to occur at densities , i.e. about 10 times larger than predicted by the equilibrium model used for Dahlia. As a result, Alth{\ae}a features a more clumpy and fragmented morphology, in turn making SN feedback more effective. Also, because of the lower density and weaker feedback, Dahlia sits away from the Schmidt-Kennicutt relation; Alth{\ae}a, instead nicely agrees with observations. The different gas properties result in widely different observables. Alth{\ae}a outshines Dahlia by a factor of 7 (15) in [CII]~ (H~) line emission. Yet, Alth{\ae}a is under-luminous with respect to the locally observed [CII]-SFR relation. Whether this relation does not apply at high-z or the line luminosity is reduced by CMB and metallicity effects remains as an open question.

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