We consider the feasibility of interpreting the anomaly in the colored Zee-Babu model. The model generates neutrino masses at two loops with the help of a scalar leptoquark and a scalar diquark , and contributes to the transition $b\to s\ell\ellS$ at tree level. Under constraints from lepton flavor violating (LFV) and flavor changing neutral current (FCNC) processes, and direct collider searches for heavy particles, we acquire certain parameter space that can accommodate the anomaly for both normal (NH) and inverted (IH) hierarchies of neutrino masses. We further examine the LFV decays of the meson, and find its strong correlation with the neutrino mass hierarchy, i.e., $(B^+ \to K^+ \mu^\pm\tau^\mp)\gtrsim(B^+ \to K^+ \mu^\pm e^\mp)\approx(B^+ \to K^+ \tau^\pm e^\mp)(B^+ \to K^+ \mu^\pm \tau^\mp)\ll(B^+ \to K^+ \mu^\pm e^\mp)\approx(B^+ \to K^+ \tau^\pm e^\mp)B^+ \to K^+ \mu^\pm e^\mp$ in the case of NH is promising at the LHCb RUN II, while for IH all LFV decays are hard to detect in the near future.

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