Quadric surface bundles over surfaces and stable rationality

We prove a general specialization theorem which implies stable irrationality for a wide class of quadric surface bundles over rational surfaces. As an application, we solve with the exception of two cases, the stable rationality problem for any very general complex projective quadric surface bundle over the projective plane, given by a symmetric matrix of homogeneous polynomials. Both exceptions degenerate over a plane sextic curve and the corresponding double cover is a K3 surface.