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In this article we are interested in the nonlocal regional Schr"odinger equation with critical exponent \begin{eqnarray*} &\epsilon^{2\alpha} (-\Delta){\rho}^{\alpha}u + u = \lambda u^q + u^{2{\alpha}^{}-1} \mbox{ in } ^{N}, \ & u \in H^{\alpha}(^{N}), \end{eqnarray} where is a small positive parameter, , $q\in (1,2_{\alpha}^{}-1)2_{\alpha}^{} = \frac{2N}{N-2\alpha}$ is the critical Sobolev exponent, is a parameter and is a variational version of the regional laplacian, whose range of scope is a ball with radius . We study the existence of a ground state and we analyze the behavior of semi-classical solutions as .

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