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For a commutative C*-algebra with unit and a Hilbert~-module , denote by End$_{\mathcal A}(\mathcal M)\mathcal A\mathcal M$, and by End the algebra of all adjointable mappings on . We prove that if is full, then each derivation on End is -linear, continuous, and inner, and each 2-local derivation on End or End is a derivation. If there exist in and in , such that , where denotes the set of all bounded -linear mappings from to , then each -linear local derivation on End is a derivation.

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