We study minimizers of the pseudo-relativistic Hartree functional under the mass constraint . Here is the mass of particles and is an external potential. We prove that minimizers exist if and only if satisfies , and there is no minimizer if , where is called the Chandrasekhar limit}. When approaches from below, the blow-up behavior of minimizers is derived under some general external potentials . Here we consider three cases of : trapping potential, i.e. satisfies ; periodic potential, i.e. $V\in C(^3)V(x+z)=V(x)z\in^3$; and ring-shaped potential, e.g. for some .

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