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We introduce the notion of the essential tangent bundle of a parametrized measure model and the notion of reduced Fisher metric on a (possibly singular) 2-integrable measure model. Using these notions and a new characterization of -integrable parametrized measure models, we extend the Cram'er-Rao inequality to -integrable (possibly singular) statistical models for general -estimations, where is a -valued feature function and is a topological vector space. Thus we derive an intrinsic Cram'er-Rao inequality in the most general terms of parametric statistics.

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