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We introduce a class of Vertex Operator Algebras which arise at junctions of supersymmetric interfaces in Super Yang Mills gauge theory. These vertex algebras satisfy non-trivial duality relations inherited from S-duality of the four-dimensional gauge theory. The gauge theory construction equips the vertex algebras with collections of modules labelled by supersymmetric interface line defects. We discuss in detail the simplest class of algebras , which generalizes algebras. We uncover tantalizing relations between , the topological vertex and the algebra.

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