The principal aim of this note is to illustrate how factorizations of singular, even-order partial differential operators yield an elementary approach to classical inequalities of Hardy-Rellich-type. More precisly, introducing the two-parameter -dimensional homogeneous scalar differential expressions $T_{\alpha,\beta} := - \Delta + \alpha |x|^{-2} x \cdot \nabla + \beta |x|^{-2}\alpha, \beta \in x \in ^n \backslash {0}n \in n \geq 2T_{\alpha,\beta}^+T_{\alpha,\beta}^+ T_{\alpha,\beta}C_0^{\infty}(^n \backslash {0})$ implies the fundamental inequality, \begin{align} \int_{^n} [(\Delta f)(x)]^2 , d^n x &\geq [(n - 4) \alpha - 2 \beta] \int_{^n} |x|^{-2} |(\nabla f)(x)|^2 , d^n x \notag \ & \quad - \alpha (\alpha - 4) \int_{^n} |x|^{-4} |x \cdot (\nabla f)(x)|^2 , d^n x \notag \ & \quad + \beta [(n - 4) (\alpha - 2) - \beta] \int_{^n} |x|^{-4} |f(x)|^2 , d^n x, \notag \end{align} for . A particular choice of values for and yields known Hardy-Rellich-type inequalities, including the classical Rellich inequality and an inequality due to Schmincke. By locality, these inequalities extend to the situation where is replaced by an arbitrary open set $\Omega \subseteq ^nf \in C^{\infty}_0(\Omega \backslash {0})$. Perhaps more importantly, we will indicate that our method, in addition to being elementary, is quite flexible when it comes to a variety of generalized situations involving the inclusion of remainder terms and higher-order situations.

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