Self-learning Monte Carlo method [arXiv:1610.03137, 1611.09364] is a powerful general-purpose numerical method recently introduced to simulate many-body systems. In this work, we implement this method in the framework of determinantal quantum Monte Carlo simulation of interacting fermion systems. Guided by a self-learned bosonic effective action, our method uses a cumulative update [arXiv:1611.09364] algorithm to sample auxiliary field configurations quickly and efficiently. We demonstrate that self-learning determinantal Monte Carlo method can reduce the auto-correlation time to as short as one near a critical point, leading to -fold speedup. This enables to simulate interacting fermion system on a lattice for the first time, and obtain critical exponents with high accuracy.

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