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We study general quadratic reaction-diffusion systems with detailed balance, in space dimension . We show that close-to-equilibrium solutions (in an sense) are regular for all times, and that they relax to equilibrium exponentially in a strong sense. That is: all detailed balance equilibria are exponentially asymptotically stable in all norms, at least in dimension . The results are given in detail for the four-species reaction-diffusion system, where the involved constants can be estimated explicitly. The main novelty is the regularity result and exponential relaxation in norms for , which up to our knowledge is new in dimensions 3 and 4.

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