For a knot in the 3-sphere and a simply connected closed 4-manifold , we define the -double slice genus of , extending the notion from the case when is the 4-sphere. We show that for each integer , there exists an algebraically doubly slice and ribbon knot whose -double slice genus is greater than . Our arguments use new -signature obstructions to embedding closed 3-manifolds with infinite cyclic first homology into closed 4-manifolds with infinite cyclic fundamental group, in a way that preserves first homology. We also extend the concept of the superslice genus of a knot to simply connected 4-manifolds and show that there exist doubly slice knots whose generalized superslice genera are arbitrarily large. Furthermore, we define the double stabilizing number of a knot, extending the stabilizing number introduced by Conway and Nagel, and show that this invariant can also be arbitrarily large.

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