A graph is called -arc-transitive if $G \le (\Gamma)\Gamma$ and the set of -arcs of , where for an integer an -arc of is a sequence of vertices of such that and are adjacent for and $v_{i-1}\ne v_{i+1}1 \le i \le s-1\Gamma((\Gamma), 2)((\Gamma), 3)\GammaGG(\Gamma)$ and non-normal otherwise. It was proved by X. G. Fang, C. H. Li and M. Y. Xu that if is a tetravalent 2-transitive Cayley graph of a finite simple group , then either is normal or is one of the groups , , and . However, it was unknown whether is normal when is one of these four groups. In the present paper we answer this question by proving that among these four groups only produces connected tetravalent 2-transitive non-normal Cayley graphs. We prove further that there are exactly two such graphs which are non-isomorphic and both determined in the paper. As a consequence, the automorphism group of any connected tetravalent 2-transitive Cayley graph of any finite simple group is determined.

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