Social media services such as Twitter are a valuable source of information for decision support systems. Many studies have shown that this also holds for the medical domain, where Twitter is considered a viable tool for public health officials to sift through relevant information for the early detection, management, and control of epidemic outbreaks. This is possible due to the inherent capability of social media services to transmit information faster than traditional channels. However, the majority of current studies have limited their scope to the detection of common and seasonal health recurring events (e.g., Influenza-like Illness), partially due to the noisy nature of Twitter data, which makes outbreak detection and management very challenging. Within the European project M-Eco, we developed a Twitter-based Epidemic Intelligence (EI) system, which is designed to also handle a more general class of unexpected and aperiodic outbreaks. In particular, we faced three main research challenges in this endeavor:

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