Following the Euclidean results of Varopoulos and Pankka–Rajala, we provide a necessary topological condition for a sub-Riemannian 3-manifold to admit a nonconstant quasiregular mapping from the sub-Riemannian Heisenberg group . As an application, we show that a link complement $S^3\backslash LL$ is empty, the unknot or Hopf link. In the converse direction, if is empty, a specific unknot or Hopf link, we construct a quasiregular mapping from to . The main result is obtained by translating a growth condition on into the existence of a supersolution to the -harmonic equation, and relies on recent advances in the study of analysis and potential theory on metric spaces.

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