We introduce Orbifold Reduction, a new method for generating gauge theories associated to D1-branes probing singular toric Calabi-Yau 4-folds starting from gauge theories on D3-branes probing toric Calabi-Yau 3-folds. The new procedure generalizes dimensional reduction and orbifolding. In terms of T-dual configurations, it generates brane brick models starting from brane tilings. Orbifold reduction provides an agile approach for generating theories with a brane realization. We present three practical applications of the new algorithm: the connection between Seiberg duality and triality, a combinatorial method for generating theories related by triality and a generalization of the Klebanov-Witten mass deformation.

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