Three general models of dynamical interacting dark energy (D-class) are investigated in the context of Brans-Dicke cosmology. All cosmological quantities such as equation of state parameters, deceleration parameters, Hubble function, and the density ratio are calculated as a function of redshift parameter. The most important part of this paper is fitting of models to the observational data (SNIa+BAO+). We obtain a table of best fit value of parameters and report and Akaike Information Criterion (AIC) for each model. By these diagnostic tools, we find that some models have no chance against CDM and some (e.g. and ) render the best fit quality. Specially, the value of AIC analysis and figures show that the interacting model fit perfectly with overall data and reveals a strong evidence in favor of this model, against CDM.

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