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Determining whether an arbitrary subring of $k[x_1^{\pm 1},\dots, x_n^{\pm 1}]$ is a normal domain is, in general, a nontrivial problem, even in the special case of a monomial generated domain. In this paper, we provide a complete characterization of the normality and normalizations of quadratic-monomial generated domains. For a quadratic-monomial generated domain , we develop a combinatorial structure that assigns, to each quadratic monomial of the ring, an edge in a mixed signed, directed graph , i.e., a graph with signed edges and directed edges. We classify the normality and the normalizations of such rings in terms of a generalization of the combinatorial odd cycle condition on .

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