In this paper, we study some relevant cosmological features of a Dark Energy (DE) model with Granda-Oliveiros cut-off, which is just a specific case of Nojiri-Odintsov holographic DE unifying phantom inflation with late-time acceleration, in the framework of Chameleon Brans-Dicke (BD) Cosmology. Choosing a particular ansatz for some of the quantities involved, we derive the expressions of some important cosmological quantities, like the Equation of State (EoS) parameter of DE , the effective EoS parameter , the pressure of DE and the deceleration parameter . Moreover, we study the behavior of statefinder parameters and , of the cosmographic parameters , , and and of the squared speed of the sound for both case corresponding to non interacting and interacting Dark Sectors. We also plot the quantities we have derived and we calculate their values for (i.e. for the beginning of the Universe history), for (i.e. for far future) and for the present time, indicated with . The EoS parameters have been tested against various observational values available in the literature.

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