We study McKean-Vlasov SDEs with interaction kernels in the local negative Sobolev space on with indexes and We derive the local well-posedness for any singular indexes and prove the global well-posedness for any initial distributions provided . Moreover, the relative entropy and the -distance induced by are estimated for the time-marginal distributions of solutions by using the Wasserstein distance of initial distributions, which describe the regularity of the solution in initial distribution. In particular, the main results apply to Nemytskii-type SDEs which depend on higher order derivatives of the density functions, as well as McKean-Vlasov SDEs with interactions more singular than Riesz kernels.

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