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In this paper, we study the Pohozaev identity associated with a Hnon-Lane-Emden system involving the fractional Laplacian: \begin{equation} \left{\begin{array}{ll} (-\triangle)^su=|x|^av^p,&x\in\Omega, (-\triangle)^sv=|x|^bu^q,&x\in\Omega, u=v=0,&x\in R^n\backslash\Omega, \end{array} \right. \end{equation} in a star-shaped and bounded domain for . As an application of our identity, we deduce the nonexistence of positive solutions in the critical and supercritical cases.

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