Let be a commutative domain with field of fractions and let be a torsion-free -algebra such that . The ring of integer-valued polynomials on with coefficients in is ${\rm Int}_K(A) = {f \in K[X] \mid f(A) \subseteq A}{\rm Int}(D) = {f \in K[X] \mid f(D) \subseteq D}D$. The condition on implies that $D[X] \subseteq {\rm Int}_K(A) \subseteq {\rm Int}(D){\rm Int}_K(A){\rm Int}_K(A) \ne D[X]DA$ is finitely generated as a -module, then is nontrivial if and only if is nontrivial. When is not necessarily finitely generated but is Dedekind, we provide necessary and sufficient conditions for to be nontrivial. These conditions also allow us to prove that, for Dedekind, the domain has Krull dimension 2.

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