The aim of this paper consists on the study of the following fourth-order operator: \begin{equation}\label{Ec::T4} T[M],u(t)\equiv u^{(4)}(t)+p_1(t),u"‘(t)+p_2(t),u"(t)+M,u(t),,\ t\in I \equiv [a,b],, \end{equation} coupled with the two point boundary conditions: \begin{equation}\label{Ec::cf} u(a)=u(b)=u"(a)=u"(b)=0,. \end{equation} So, we define the following space: \begin{equation}\label{Ec::esp} X=\left\lbrace u\in C^4(I)\quad\mid\quad u(a)=u(b)=u"(a)=u"(b)=0 \right\rbrace ,. \end{equation} Here and . By assuming that the second order linear differential equation \begin{equation}\label{Ec::2or} L_2, u(t)\equiv u"(t)+p_1(t),u’(t)+p_2(t),u(t)=0,,\quad t\in I, \end{equation} is disconjugate on , we characterize the parameter’s set where the Green’s function related to operator in is of constant sign on . Such characterization is equivalent to the strongly inverse positive (negative) character of operator on and comes from the first eigenvalues of operator on suitable spaces.

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