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We consider the cosmetic surgery problem for two-bridge knots in the 3-sphere. It is seen that all the two-bridge knots at most 9 crossings other than admits no purely cosmetic surgery pairs. Then we show that any two-bridge knot of the Conway form with admits no cosmetic surgery pairs yielding homology 3-spheres, where appears for . Our advantage to prove this is using the Casson invariant.

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