We argue that the diphoton excess recently reported by ATLAS and CMS can be explained, along with several anomalies seen in the flavor sector, in models where a Standard-Model singlet scalar resonance with mass GeV is produced in gluon fusion via loops containing a scalar color- triplet leptoquark . For a leptoquark mass 1 TeV, the production cross section is naturally in the 10 fb range. A large $S \to \gamma \gamma$ branching ratio can be obtained by coupling the scalar S to new color-singlet fermions with electroweak scale masses, which can be part of an multiplet, whose neutral component has the right mass and quantum numbers to be a dark matter candidate. Our model reveals a connection between flavor anomalies, the nature of dark matter and a new scalar, which acts as a mediator to the dark sector. The loop-mediated decay $S \to \tau^+\tau^-$ could be a striking signature of this model.

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