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Motivated by the sharp constants in the -Caffarelli–Kohn–Nirenberg (or -CKN for short) inequalities on Euclidean spaces, we study, in a unified framework, a sequence of -CKN inequalities on metric measure spaces. On a general metric measure space, this sequence implies a reverse volume comparison of Günther type. Moreover, on a subclass of spaces admitting the measure contraction property, we show that this sequence of -CKN inequalities are valid if and only if the spaces are volume cones. We also provide a stability result for inequalities of this type on volume cones.

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