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Four-dimensional super Yang-Mills theory admits interfaces that preserve integrability of the theory. It was shown that addition of fundamental hypermultiplets living on a co-dimension one defect is an example of such an interface. We consider NS5 interface as a different example of half-BPS defect in this theory and prove that integrability is generically broken already at one loop. We show that one-loop dilatation operator acting on boundary local operators does not lead to an integrable spin chain. The same is true also for D5-like and NS5-like boundaries.

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