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Let denote a bipartite graph with edges without isolated vertices. It was known that the spectral radius of is at most the square root of , and the upper bound is attained if and only if is a complete bipartite graph. Suppose that is not a complete bipartite graph, and and are not twin primes. We determine the maximal spectral radius of . As a byproduct of our study, we obtain a spectral characterization of a pair $(e-1, e+1)$ of integers to be a pair of twin primes.

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