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We discuss recent progress in the study of in-medium heavy quarkonium using first-principles lattice QCD calculations and effective field theory. In particular our focus lies on real-time information carried by QCD spectral functions and we report on a novel strategy for their extraction from Euclidean-time simulations. Combining an effective description for heavy quarks with finite temperature lattice QCD we compute in-medium spectra providing insight in heavy quarkonium melting in a static thermal medium. On the other hand we use spectral information to extract the complex in-medium potential which provides the basis for a dynamical description of quarkonium real-time evolution via the Schr"odinger equation.

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