We introduce a new approach to investigate the selection rules governing the
contributions of fluxed M5-instantons to the F-theory four-dimensional
effective action, with emphasis on the generation of charged matter F-terms.
The structure of such couplings is unraveled by exploiting the perturbative and
non-perturbative homological relations, introduced in our companion paper
arXiv:1506.06764, which encode the interplay between the self-dual 3-form flux
on the M5-brane, the background 4-form flux and certain fibral curves. The
latter are wrapped by time-like M2-branes representing matter insertions in the
instanton path integral. In particular, we clarify how fluxed M5-instantons
detect the presence of geometrically massive s which are responsible for
hidden' selection rules. We discuss how for non-generic embeddings the M5-instanton can probe locally massless’ symmetries if the rank of its
Mordell-Weil group is enhanced compared to that of the bulk. As a
phenomenological off-spring we propose a new type of non-perturbative
corrections to Yukawa couplings which may change the rank of the Yukawa matrix.
Along the way, we also gain new insights into the structure of massive
gauge fluxes in the stable degeneration limit.

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