We study chiral deformations of and supersymmetric gauge theories obtained by turning on interactions with the superfield. Using localization, we compute the deformed gauge theory partition function and the expectation value of circular Wilson loops on a squashed four-sphere. In the case of the deformed theory, exact formulas for and are derived in terms of an underlying interacting matrix model replacing the free Gaussian model describing the theory. Using the AGT correspondence, the -deformations are related to the insertions of commuting integrals of motion in the four-point CFT correlator and chiral correlators are expressed as -derivatives of the gauge theory partition function on a finite -background. In the so called Nekrasov-Shatashvili limit, the entire ring of chiral relations is extracted from the -deformed Seiberg-Witten curve. As a byproduct of our analysis we show that gauge theories on rational -backgrounds are dual to CFT minimal models.

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