We introduce and study a general pseudodifferential calculus for boundary value problems on a class of non-compact manifolds with boundary (so-called Lie manifolds with boundary). This is accomplished by constructing a suitable generalization of the Boutet de Monvel calculus for boundary value problems. The data consists of a compact manifold with corners that is endowed with a Lie structure of vector fields , a so-called Lie manifold. The manifold is split into two equal parts and which intersect in an embedded hypersurface . Our goal is to describe a transmission Boutet de Monvel calculus for boundary value problems compatible with the structure of Lie manifolds. Starting with the example of -vector fields, we show that there are two groupoids integrating the Lie structures on and on , respectively. These two groupoids form a bibundle (or a groupoid correspondence) and, under some mild assumptions, these groupoids are Morita equivalent. With the help of the bibundle structure and canonically defined manifolds with corners, which are blow-ups in particular cases, we define a class of Boutet de Monvel type operators. We then define the representation homomorphism for these operators and show closedness under composition with the help of a representation theorem. Finally, we consider appropriate Fredholm conditions and construct the parametrices for elliptic operators in the calculus.

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