Supernovae (SN), the most energetic stellar feedback mechanism, are crucial for regulating the interstellar medium (ISM) and launching galactic winds. We explore how supernova remnants (SNRs) create a multiphase medium by performing 3D hydrodynamical simulations at various SN rates, , and ISM average densities, . The evolution of a SNR in a self-consistently generated three-phase ISM is qualitatively different from that in a uniform or a two-phase warm/cold medium. By travelling faster and further in the low-density hot phase, the domain of a SNR increases by . Varying and , we find that a steady state can only be achieved when the hot gas volume fraction . Above that level, overlapping SNRs render connecting topology of the hot gas, and the ISM is subjected to thermal runaway. Photoelectric heating (PEH) has a surprisingly strong impact on . For , a reasonable PEH rate is able to suppress the thermal runaway. Overall, we determine the critical SN rate for the onset of thermal runaway to be $S_{\rm{crit}} = 200 (\bar{n}/1\cm-3)^k (E_{\rm{SN}}/10^{51}\erg)^{-1} \kpc^{-3} \myr-1k = (1.2,2.7)\bar{n} \leq 1> 1\cm-3 $, respectively. We present a fitting formula of the ISM pressure , ), which can be used as an effective equation of state in cosmological simulations. Despite the 5 orders of magnitude span of , the average Mach number varies little: for the hot, warm and cold phases, respectively.

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