We develop a unified framework for the design and analysis of high-order nonconforming virtual element methods for nonlinear fourth-order reaction–diffusion problems in two dimensions, with emphasis on clamped, Navier, and Cahn–Hilliard-type boundary conditions. Time discretization is performed using the backward Euler scheme, while the spatial approximation relies on nonconforming virtual element spaces of arbitrary order , encompassing both -nonconforming and Morley-type methods. A key contribution of this work is the development of a novel and rigorous unified error analysis for these numerical schemes, applicable to domains that are not necessarily convex, differing from the existing literature. By introducing a class of Companion operators, we construct novel Ritz-type projections and derive a new error equation that enables us to obtain optimal error estimates for the scheme under a minimal spatial regularity assumption on the weak solution. Finally, we present numerical experiments on polygonal meshes as applications of the proposed framework, including the extended Fisher–Kolmogorov equation, and a fourth-order model with Cahn–Hilliard-type boundary conditions, which validate the theoretical results and illustrate the performance of the method for the three classes of boundary conditions.

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