In this paper we investigate Diophantine equations of the form , where or and is specific homogenous quintic form. First, we prove that if and $(b-2,4a-d^2,d)\neq (0,0,0)t^2=nxyzF(x,y,z)$ has solution in polynomials with integer coefficients, without polynomial common factor of positive degree. In case we prove that there are infinitely many primitive integer solutions of the Diophantine equation under consideration. As an application of our result we prove that for each the Diophantine equation \begin{equation*} T^2=n(X_{1}^5+X_{2}^5+X_{3}^5+X_{4}^5) \end{equation*} has a solution in co-prime (non-homogenous) polynomials in two variables with integer coefficients. We also present a method which sometimes allow us to prove the existence of primitive integers solutions of more general quintic Diophantine equation of the form , where $a, b, c, d\in\Zm, n\in\Z\setminus{0},$ the Diophantine equation \begin{equation*} T^2=m(X_{1}^5-X_{2}^5)+n^2(X_{3}^5-X_{4}^5) \end{equation*} has a solution in polynomials which are co-prime over . Moreover, we show how modification of the presented method can be used in order to prove that for each , the Diophantine equation \begin{equation*} t^2=n(X_{1}^5+X_{2}^5-2X_{3}^5) \end{equation*} has a solution in polynomials which are co-prime over .

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