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This paper is concerned with the Cauchy problem for the modified two-dimensional (2D) nonhomogeneous incompressible Navier-Stokes equations with density-dependent viscosity. By fully using the structure of the system, we can obtain the key estimates of without any smallness asuumption on the initial data, and thus establish the global existence of the strong solutions with the far-field density being either vacuum or nonvacuum. Notably, the initial data can be arbitrarily large and the initial density is allowed to vanish. Furthermore, the large-time asymptotic behavior of the gradients of the velocity and the pressure is also established.

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