The effects of isotopic invariance violation in the processes , , and are considered in the energy range between the thresholds of and production. The analysis is based on taking into account the final-state interaction in a six-channel problem. Our approach allowed us to obtain good agreement with recent Belle-II results for the ratio of the and production cross sections in annihilation in the vicinity of . It is shown that at higher energies the ratios of the cross sections for pairs of neutral and charged mesons can differ significantly from unity. A detailed measurement of this effect will provide evidence that the nontrivial energy dependence of the production cross sections is a consequence of interference of the particle production amplitudes in the multichannel problem.

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