Motivated by the Pati-Salam Grand Unified Theory, we study topological insulators with symmetry, whose boundary has 16 flavors of left-chiral fermions, which form representations and $(\bar{}, , )$. The key result we obtain is that, without any interaction, this topological insulator has a classification, namely any quadratic fermion mass operator at the boundary is prohibited by the symmetries listed above; while under interaction this system becomes trivial, namely its boundary can be gapped out by a properly designed short range interaction without generating nonzero vacuum expectation value of any fermion bilinear mass, or in other words, its boundary can be driven into a “strongly coupled symmetric gapped (SCSG) phase”. Based on this observation, we propose that after coupling the system to a dynamical lattice gauge field, the Pati-Salam GUT can be fully regularized as the boundary states of a topological insulator with a {\it thin} fourth spatial dimension, the thin fourth dimension makes the entire system generically a system. The mirror sector on the opposite boundary will {\it not} interfere with the desired GUT, because the mirror sector is driven to the SCSG phase by a carefully designed interaction and is hence decoupled from the GUT.

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