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We study the existence of positive solution for the one dimensional Schr"odinger equation with mixed Lioville-Weyl fractional derivatives \begin{eqnarray*}\label{Eq00} {t}D{\infty}^{\alpha}({{-\infty}}D{t}^{\alpha}u(t)) + V(t) u(t) = & f(u(t)),;;t\in \ u\in H^{\alpha}().\nonumber \end{eqnarray*} Furthermore, we analyse radial symmetry property of these solutions. The proof is carried out by using variational methods jointly with comparison and rearrangement argument.

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