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Generalized susceptibilities of the net quark number have been proposed to be good probes for the transitions in the QCD phase diagram and for the search of a possible critical end point. In this article we explore a new strategy for computing quark number susceptibilities from lattice QCD via an expansion in the fugacity parameter . All quark number related bulk observables are particularly easy to access in this approach and we present results for generalized quark number susceptibilities up to 4-th order. Ratios of these quantities are studied and compared with model calculations for the high- and low temperature regions up to a chemical potential of .

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